hDHODH-IN-3

• CAT Number: I016874
• CAS Number: 1644156-80-8
• Molecular Formula: C₁₈H₁₉BrN₄O₂
• Molecular Weight: 403.27
• Purity: ≥95%
• IUPAC Name: 2-[4-(2-bromophenoxy)-3-ethoxy-5-methylpyrazol-1-yl]-5-ethylpyrimidine
• InChI: InChI=1S/C18H19BrN4O2/c1-4-13-10-20-18(21-11-13)23-12(3)16(17(22-23)24-5-2)25-15-9-7-6-8-14(15)19/h6-11H,4-5H2,1-3H3
• InChIKey: SNDPFEDGFPXNIX-UHFFFAOYSA-N
• SMILES: CCC1=CN=C(N=C1)N2C(=C(C(=N2)OCC)OC3=CC=CC=C3Br)C

hDHODH-IN-3（Cat No.:I016874）is a potent and selective inhibitor of human dihydroorotate dehydrogenase (hDHODH), an essential enzyme in the pyrimidine biosynthesis pathway. By blocking hDHODH activity, this compound disrupts the synthesis of pyrimidine nucleotides, which are crucial for DNA and RNA production in rapidly proliferating cells, such as cancer cells and immune cells. hDHODH-IN-3 has shown promise in preclinical studies as a therapeutic candidate for autoimmune diseases and certain cancers, making it a valuable tool for investigating targeted inhibition in drug development.

Reference

[1]. Lucas-Hourani M, et al. Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.