hDHODH-IN-4

• CAT Number: I017111
• CAS Number: 1644156-56-8
• Molecular Formula: C₂₁H₂₄N₄O₂
• Molecular Weight: 364.44
• Purity: ≥95%
• IUPAC Name: [1-(5-cyclopropylpyrimidin-2-yl)-5-methyl-3-propan-2-yloxypyrazol-4-yl]-phenylmethanol
• InChI: InChI=1S/C21H24N4O2/c1-13(2)27-20-18(19(26)16-7-5-4-6-8-16)14(3)25(24-20)21-22-11-17(12-23-21)15-9-10-15/h4-8,11-13,15,19,26H,9-10H2,1-3H3
• InChIKey: BSNKBAPMWCMENP-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1C2=NC=C(C=N2)C3CC3)OC(C)C)C(C4=CC=CC=C4)O

hDHODH-IN-4（Cat No.:I017111）is a selective inhibitor of human dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. By targeting DHODH, this high-purity compound is essential for research in immunology and oncology, where DHODH inhibition disrupts nucleotide synthesis, impacting cell proliferation. hDHODH-IN-4 is particularly useful in studying immune modulation and cancer cell growth suppression. With stable efficacy and specificity, it enables in-depth exploration of DHODH as a therapeutic target, supporting the development of innovative strategies in autoimmune and cancer therapy research.

Reference

[1]. Munier-Lehmann H, et al. Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). J Med Chem. 2015 Jan 22;58(2):860-77.