HDM-201

• CAT Number: I011408
• CAS Number: 1448867-41-1
• Molecular Formula: C26 H24 Cl2 N6 O4
• Molecular Weight: 555.41
• Purity: ≥95%
• Synonyms: (6S)-5-(5-Chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)pyrrolo[3,4-d]imidazol-4(1H)-one
• Target: Metabolic Enzyme/Protease
• Storage: -20°C
• IUPAC Name: (4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
• InChI: 1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1
• InChIKey: AGBSXNCBIWWLHD-FQEVSTJZSA-N
• SMILES: CC(C)N1C2=C(C(=O)N([C@H]2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC

HDM-201(CAT: I011408) is an orally bioavailable inhibitor of human double minute 2 homolog (HDM2). HDM2 is a protein that negatively regulates the tumor suppressor protein p53, which plays a critical role in cell cycle regulation and apoptosis. By inhibiting HDM2, HDM-201 has the potential to restore the activity of p53 and promote tumor cell death. As a result, HDM-201 shows promise as an antineoplastic agent for the treatment of cancer. Its oral bioavailability makes it a convenient option for administration. Ongoing research aims to further evaluate its efficacy and safety in clinical trials.