HEI3090

• CAT Number: I047658
• CAS Number: 2377167-56-9
• Molecular Formula: C18H15Cl3N4O3
• Molecular Weight: 441.7
• Purity: ≥95%
• IUPAC Name: (2S)-1-N-(6-chloropyridin-3-yl)-2-N-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-1,2-dicarboxamide
• InChI: InChI=1S/C18H15Cl3N4O3/c19-11-2-1-10(13(20)7-11)8-23-17(27)14-4-6-16(26)25(14)18(28)24-12-3-5-15(21)22-9-12/h1-3,5,7,9,14H,4,6,8H2,(H,23,27)(H,24,28)/t14-/m0/s1
• SMILES: C1CC(=O)N([C@@H]1C(=O)NCC2=C(C=C(C=C2)Cl)Cl)C(=O)NC3=CN=C(C=C3)Cl

HEI3090 is a positive modulator of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung tumors in transplantable and oncogene-induced mouse models and triggers long lasting antitumor immune responses.
KEYWORDS: HEI3090 | Supplier | P2X7 activator | HEI 3090 | HEI-3090 | CAS [2377167-56-9] | Non Selective (Cations) | P2X7 | Activator | Ion Channels | Lung tumor | NSCLC | Antitumor immunity

Reference

L Douguet et al. A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy. Nat Commun. 2021 Jan 28;12(1):653.