Helioxanthin derivative 5-4-2

• CAT Number: I002574
• CAS Number: 203935-39-1
• Molecular Formula: C20H13NO5
• Molecular Weight: 347.32
• Purity: ≥95%
• Synonyms: 10-(benzo[d][1,3]dioxol-5-yl)-9H-[1,3]dioxolo[4/’,5/’:3,4]benzo[1,2-f]isoindol-7-ol
• Target: HBV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.08 uM (EC50) [1][2]
• IUPAC Name: 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-[1,3]benzodioxolo[7,6-f]isoindol-7-one
• InChI: InChI=1S/C20H13NO5/c22-20-12-5-10-2-4-15-19(26-9-24-15)18(10)17(13(12)7-21-20)11-1-3-14-16(6-11)25-8-23-14/h1-6H,7-9H2,(H,21,22)
• InChIKey: UVKXTQRJKHBAMT-UHFFFAOYSA-N
• SMILES: C1C2=C(C=C3C=CC4=C(C3=C2C5=CC6=C(C=C5)OCO6)OCO4)C(=O)N1

Helioxanthin derivative 5-4-2（Cat No.:I002574）is a synthetic analogue of helioxanthin, exhibiting significant antiviral activity against hepatitis B virus (HBV). In vitro studies demonstrate an EC₅₀ of 0.08 μM in HepG2.2.15 cells, indicating potent efficacy.This compound inhibits HBV DNA replication, mRNA transcription, and protein expression, including in lamivudine-resistant strains. Its mechanism involves disrupting viral gene expression and replication processes. Due to its high potency and broad antiviral spectrum, Helioxanthin derivative 5-4-2 is a promising candidate for further research in HBV therapeutics.

Reference

[1]. Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2]. Li Y, et al. Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.