For research use only. Not for therapeutic Use.
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1].
Heme Oxygenase-1-IN-1 (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells[2].
Heme Oxygenase-1-IN-1 (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells[3].
Heme Oxygenase-1-IN-1 significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells[3].
| Catalog Number | I019270 |
| CAS Number | 1093058-52-6 |
| Synonyms | 1-[4-(4-bromophenyl)butyl]imidazole |
| Molecular Formula | C13H15BrN2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H15BrN2/c14-13-6-4-12(5-7-13)3-1-2-9-16-10-8-15-11-16/h4-8,10-11H,1-3,9H2 |
| InChIKey | FZNINMHMRBYDPR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CCCCN2C=CN=C2)Br |
| Reference | [1]. Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. [2]. Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. [3]. Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. |
