Hemin

• CAT Number: I002035
• CAS Number: 16009-13-5
• Molecular Formula: C34H30ClFeN4O4 • 2H
• Molecular Weight: 651.94
• Purity: ≥95%
• Synonyms: Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)
• Target: Apoptosis
• Solubility: DMSO: ≤ 6.6 mg/mL
• Storage: Store at 2°C to 8°C
• IUPAC Name: 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride
• InChI: InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+3/p-2/b25-13-,26-13-,27-14-,28-15-,2
• InChIKey: BTIJJDXEELBZFS-HXFTUNQESA-K
• SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Fe+3]35([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]

Hemin (CAT: I002035) is a synthetic form of heme, a molecule essential for various biological processes. It acts as a potent inducer of heme oxygenase-1 (HO-1), an enzyme involved in the breakdown of heme. Hemin has been studied for its therapeutic potential in various conditions, including acute porphyria, a group of genetic disorders characterized by abnormal heme metabolism. By inducing HO-1, hemin helps to alleviate symptoms and reduce the accumulation of toxic heme intermediates in patients with acute porphyria. Additionally, hemin has shown anti-inflammatory and antioxidant properties, making it a promising candidate for the treatment of other inflammatory and oxidative stress-related diseases.