Henagliflozin

• CAT Number: I007200
• CAS Number: 1623804-44-3
• Molecular Formula: C22H24ClFO7
• Molecular Weight: 454.875
• Purity: ≥95%
• Synonyms: SHR3824; SHR-3824; SHR 3824; Henagliflozin;(1R,2S,3S,4R,5R)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
• Target: SGLT
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: (1R,2S,3S,4R,5R)-5-[4-chloro-3-[(4-ethoxy-3-fluorophenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
• InChI: InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22+/m0/s1
• InChIKey: HYTPDMFFHVZBOR-VNXMGFANSA-N
• SMILES: CCOC1=C(C=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl)F

Henagliflozin is a potent and selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, primarily used in diabetes research. By inhibiting SGLT2, henagliflozin reduces glucose reabsorption in the kidneys, promoting glucose excretion and lowering blood glucose levels. This mechanism offers a novel approach to managing type 2 diabetes by addressing hyperglycemia independent of insulin pathways. Henagliflozin’s efficacy in improving glycemic control, along with potential benefits for weight loss and cardiovascular health, makes it a promising compound for the study and development of antidiabetic therapies.