Herbimycin A

• CAT Number: I010434
• CAS Number: 70563-58-5
• Molecular Formula: C₃₀H₄₂N₂O₉
• Molecular Weight: 574.70
• Purity: ≥95%
• Synonyms: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
• Target: Src
• Solubility: Soluble to 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: [(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
• InChI: InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• InChIKey: MCAHMSDENAOJFZ-BVXDHVRPSA-N
• SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)\C)C)OC)OC

Herbimycin A（Cat No.:I010434）is a benzoquinonoid ansamycin antibiotic known for its inhibitory effects on protein tyrosine kinases, particularly targeting oncogenic kinases involved in cancer cell growth. By binding to the ATP-binding site, it disrupts kinase activity, leading to reduced phosphorylation of proteins critical for cell signaling, growth, and survival. Herbimycin A is extensively used in research to study cancer signaling pathways and the role of tyrosine kinases in disease progression. Additionally, it has shown potential in reversing certain drug resistance mechanisms, making it a valuable tool in cancer and molecular biology research.

Reference

Eichhorn, Kai. /Geldanamycin: The Prototype of a Class of Antitumor Drugs Targeting the Heat Shock Protein 90 Family of Molecular Chaperones./ Cell Stress Chaperones6.2 (2001): 105-12. www.ncbi.gov. Web. 6 Sept. 2012.