For research use only. Not for therapeutic Use.
Hesperadin（Cat No.:I003520）is a selective small-molecule inhibitor of Aurora B kinase, a key enzyme involved in cell division. By inhibiting Aurora B, Hesperadin disrupts chromosome alignment and segregation during mitosis, leading to abnormal cell division and apoptosis. It has shown potential in cancer research, particularly in targeting rapidly dividing cancer cells. Hesperadin’s ability to induce mitotic defects makes it a valuable tool for studying cell cycle regulation and cancer progression. Researchers explore its use as a therapeutic agent in various cancers, aiming to enhance the effectiveness of existing treatments.
| Catalog Number | I003520 |
| CAS Number | 422513-13-1 |
| Synonyms | N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide |
| Molecular Formula | C₂₉H₃₂N₄O₃S |
| Purity | ≥95% |
| Target | Aurora Kinase |
| Solubility | DMSO ≥101mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 250 nM |
| Reference | </br>1:Synthesis and investigation of new Hesperadin analogues antitumor effects on HeLa cells. Shamsipour F, Hosseinzadeh S, Arab SS, Vafaei S, Farid S, Jeddi-Tehrani M, Balalaie S.J Chem Biol. 2014 May 18;7(3):85-91. doi: 10.1007/s12154-014-0111-3. eCollection 2014 Jul. PMID: 25077005 Free PMC Article</br>2:The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Jetton N, Rothberg KG, Hubbard JG, Wise J, Li Y, Ball HL, Ruben L.Mol Microbiol. 2009 Apr;72(2):442-58. doi: 10.1111/j.1365-2958.2009.06657.x. Epub 2009 Mar 6. PMID: 19320832 Free PMC Article</br>3:[Effect of the pharmacological agent hesperadin on breast and prostate tumor cultured cells]. Ladygina NG, Latsis RV, Yen T.Biomed Khim. 2005 Mar-Apr;51(2):170-6. Russian. PMID: 15945350 </br>4:Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A.Mol Cell. 2005 Apr 29;18(3):379-91. PMID: 15866179 Free Article</br>5:The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21. PMID: 12707311 Free PMC Article |
