For research use only. Not for therapeutic Use.
Hesperetin (Cat No.:I003887) is a natural flavonoid compound found in citrus fruits, particularly in the peel and pulp. It exhibits various pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. Hesperetin has been studied for its potential health benefits, such as reducing oxidative stress, inhibiting inflammation, and exerting anticancer effects by modulating various cellular pathways. It has also shown promise in the treatment and prevention of cardiovascular diseases, neurodegenerative disorders, and metabolic disorders. Further research is ongoing to explore its therapeutic potential and elucidate its mechanisms of action.
| Catalog Number | I003887 |
| CAS Number | 520-33-2 |
| Synonyms | 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one |
| Molecular Formula | C16H14O6 |
| Purity | ≥95% |
| Solubility | 30 mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one |
| InChI | InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1 |
| InChIKey | AIONOLUJZLIMTK-AWEZNQCLSA-N |
| SMILES | COC1=C(C=C(C=C1)[C@@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| Reference | </br>1:Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters. Babukumar S, Vinothkumar V, Velu P, Ramachandhiran D, Ramados Nirmal M.Arch Physiol Biochem. 2017 May 1:1-14. doi: 10.1080/13813455.2017.1317815. [Epub ahead of print] PMID: 28457144 </br>2:Is failure of cocrystallization actually a failure? Eutectic formation in cocrystal screening of hesperetin. Chadha K, Karan M, Chadha R, Bhalla Y, Vasisht K.J Pharm Sci. 2017 Apr 26. pii: S0022-3549(17)30274-5. doi: 10.1016/j.xphs.2017.04.038. [Epub ahead of print] PMID: 28456725 </br>3:Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl<sub>4</sub>-induced acute liver injury and LPS-treated RAW264.7 cells. Chen X, Ding HW, Li HD, Huang HM, Li XF, Yang Y, Zhang YL, Pan XY, Huang C, Meng XM, Li J.Toxicol Lett. 2017 May 15;274:51-63. doi: 10.1016/j.toxlet.2017.04.008. Epub 2017 Apr 18. PMID: 28428136 </br>4:The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration. Xue D, Chen E, Zhang W, Gao X, Wang S, Zheng Q, Pan Z, Li H, Liu L.Oncotarget. 2017 Mar 28;8(13):21031-21043. doi: 10.18632/oncotarget.15473. PMID: 28423500 Free PMC Article</br>5:Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study. Zareei S, Boojar MM, Amanlou M.Life Sci. 2017 Apr 3. pii: S0024-3205(17)30119-4. doi: 10.1016/j.lfs.2017.04.001. [Epub ahead of print] PMID: 28385612 </br>6:The effects of Nobiletin, Hesperetin, and Letrozole in a combination on the activity and expression of aromatase in breast cancer cells. Rahideh ST, Keramatipour M, Nourbakhsh M, Koohdani F, Hoseini M, Shidfar F.Cell Mol Biol (Noisy-le-grand). 2017 Feb 28;63(2):9-13. doi: 10.14715/cmb/2017.63.2.2. PMID: 28364779 </br>7:Effect of hesperetin on chaperone activity in selenite-induced cataract. Nakazawa Y, Oka M, Tamura H, Takehana M.Open Med (Wars). 2016 Jun 15;11(1):183-189. doi: 10.1515/med-2016-0035. eCollection 2016. PMID: 28352791 Free PMC Article</br>8:Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery. Menezes PD, Frank LA, Lima BD, de Carvalho YM, Serafini MR, Quintans-Júnior LJ, Pohlmann AR, Guterres SS, Araújo AA.Int J Nanomedicine. 2017 Mar 15;12:2069-2079. doi: 10.2147/IJN.S124564. eCollection 2017. PMID: 28352176 Free PMC Article</br>9:Inhibitory effect of hesperetin on α-glucosidase: Molecular dynamics simulation integrating inhibition kinetics. Gong Y, Qin XY, Zhai YY, Hao H, Lee J, Park YD.Int J Biol Macromol. 2017 Mar 18;101:32-39. doi: 10.1016/j.ijbiomac.2017.03.072. [Epub ahead of print] PMID: 28322965 </br>10:The renoprotective activity of hesperetin in cisplatin induced nephrotoxicity in rats: Molecular and biochemical evidence. Kumar M, Dahiya V, Kasala ER, Bodduluru LN, Lahkar M.Biomed Pharmacother. 2017 May;89:1207-1215. doi: 10.1016/j.biopha.2017.03.008. Epub 2017 Mar 14. PMID: 28320087 |
