For research use only. Not for therapeutic Use.
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HETERATISINE(cas 3328-84-5) is a potent antiarrhythmic and antifibrillatory. It is a Na<sup>+</sup>-channel blocker in cardiomyocytes.
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C<sub>19</sub>-norditerpenoid alkaloid<!–C<sub>22</sub>H<sub>33</sub>NO<sub>5</sub>–>, from <i>Aconitum heterophyllum</i> of the Ranunculaceae family.<br />
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It has antiarrhythmic and antifibrillatory activity on experimental arrhythmias caused by <strong>Aconitine</strong>, calcium chloride, cardiac electric stimulation and artery occlusion. The active dosage ranges from 5 to 20 mg/kg in mammals. <br />
<strong>Heteratisine </strong>is more active, more cardioselective and less toxic than <strong>Quinidine</strong>.
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| Catalog Number | T000066 |
| CAS Number | 3328-84-5 |
| Synonyms | 20-Ethyl-6β,8-dihydroxy-1α-methoxy-4-methylheteratisan-14-one |
| Molecular Formula | C22H33NO5 |
| Purity | ≥95% |
| Solubility | In chloroform and methanol<br>Not well in acetone and ethanol |
| Storage | Store at +4°C, in dark place. 20 mg of Heteratisine dissolve in 0.3 ml 3 % HCl. |
| Reference | – Pelletier et al., Phytochemistry (1968). 7:625<br /> |
