For research use only. Not for therapeutic Use.
Hexamethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based linker commonly employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This linker consists of a PEG chain with six ethylene glycol units and a methyl ether group. Hexamethylene glycol monomethyl ether provides flexibility and hydrophilicity, enabling the connection between the target protein-binding ligand and the E3 ubiquitin ligase-recruiting moiety in PROTACs. Its use facilitates the construction of PROTAC molecules that can induce target protein degradation, offering a versatile tool for the development of novel targeted therapies and chemical biology studies.
| Catalog Number | I015615 |
| CAS Number | 23601-40-3 |
| Molecular Formula | C₁₃H₂₈O₇ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Storage | -20°C |
| IUPAC Name | 2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| InChI | InChI=1S/C13H28O7/c1-15-4-5-17-8-9-19-12-13-20-11-10-18-7-6-16-3-2-14/h14H,2-13H2,1H3 |
| InChIKey | FHHGCKHKTAJLOM-UHFFFAOYSA-N |
| SMILES | COCCOCCOCCOCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
