Hexafluorenium Bromide

• CAT Number: R025024
• CAS Number: 317-52-2
• Molecular Formula: C36H42Br2N2
• Molecular Weight: 662.554
• Purity: ≥95%
• Synonyms: Hexafluorenium Dibromide; Hexafluronium Bromide; Hexamethylenebis(9-fluorenyldimethylammonium) Dibromide; Hexamethylenebis[dimethyl-9-fluorenylammonium Bromide]; Mylaxen; B 141; Hexamethylenebis[fluoren-9-yldimethylammonium Bromide]; N,N’-Di-9H-fluor
• Target: Cholinesterase (ChE)
• Storage: -20°C
• IUPAC Name: 9H-fluoren-9-yl-[6-[9H-fluoren-9-yl(dimethyl)azaniumyl]hexyl]-dimethylazanium;dibromide
• InChI: InChI=1S/C36H42N2.2BrH/c1-37(2,35-31-21-11-7-17-27(31)28-18-8-12-22-32(28)35)25-15-5-6-16-26-38(3,4)36-33-23-13-9-19-29(33)30-20-10-14-24-34(30)36;;/h7-14,17-24,35-36H,5-6,15-16,25-26H2,1-4H3;2*1H/q+2;;/p-2
• InChIKey: WDEFPRUEZRUYNW-UHFFFAOYSA-L
• SMILES: C[N+](C)(CCCCCC[N+](C)(C)C1C2=CC=CC=C2C3=CC=CC=C13)C4C5=CC=CC=C5C6=CC=CC=C46.[Br-].[Br-]

Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block the activity of plasma cholinesterases. Hexafluronium acts as a nicotinic acetylcholine receptor antagonist.

Reference

1:Anesth Analg. 1973 Jan-Feb;52(1):100-5. Hexafluorenium bromide: current status and a review.Britton RM,Figueroa M, PMID: 4567515