Hexamethonium chloride

• CAT Number: I028719
• CAS Number: 60-25-3
• Molecular Formula: C12H30Cl2N2
• Molecular Weight: 273.29
• Purity: 98%
• Synonyms: Hexamethonium chloride; NSC 21643; NSC-21643; NSC21643
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium chloride
• InChI: InChI=1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
• InChIKey: PYIHTIJNCRKDBV-UHFFFAOYSA-L
• SMILES: C[N+](C)(CCCCCC[N+](C)(C)C)C.[Cl-].[Cl-]

Hexamethonium Chloride(CAT: I028719) is a preferential blocker of nicotinic acetylcholine receptors at autonomic ganglia, effectively inhibiting signal transmission in the autonomic nervous system. It is used in pharmacological research to study ganglionic neurotransmission and autonomic function. While its primary action is peripheral, it has been shown to cross the blood-brain barrier at high doses, allowing for potential exploration of central nervous system effects under specific conditions. Hexamethonium Chloride is a valuable tool for investigating autonomic regulation and the role of nicotinic receptors in physiological and pathological processes.