Hexanoyl Glycine

• CAT Number: R009838
• CAS Number: 24003-67-6
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Purity: ≥95%
• Synonyms: N-(1-Oxohexyl)glycine; Caproylglycine; N-Caproylglycine; NSC 224460; n-Hexanoylglycine
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: 2-(hexanoylamino)acetic acid
• InChI: InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)
• InChIKey: UPCKIPHSXMXJOX-UHFFFAOYSA-N
• SMILES: CCCCCC(=O)NCC(=O)O

Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).