Hexapeptide-11

  • CAT Number: I028730
  • CAS Number: 161258-30-6
  • Molecular Formula: C36H48N6O7
  • Molecular Weight: 676.81
  • Purity: 98%
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Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.


Catalog Number I028730
CAS Number 161258-30-6
Synonyms

Hexapeptide-11; Peptamide 6; Fvapfp; Phe-val-ala-pro-phe-pro;

Molecular Formula C36H48N6O7
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name L-phenylalanyl-L-valyl-L-alanyl-L-prolyl-L-phenylalanyl-L-proline
InChI InChI=1S/C36H48N6O7/c1-22(2)30(40-31(43)26(37)20-24-12-6-4-7-13-24)33(45)38-23(3)34(46)41-18-10-16-28(41)32(44)39-27(21-25-14-8-5-9-15-25)35(47)42-19-11-17-29(42)36(48)49/h4-9,12-15,22-23,26-30H,10-11,16-21,37H2,1-3H3,(H,38,45)(H,39,44)(H,40,43)(H,48,49)/t23-,26-,27-,28-,29-,30-/m0/s1
InChIKey GFEYWOGCSROPRT-OBXVVNIGSA-N
SMILES O=C(O)[C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H]3N(C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC4=CC=CC=C4)N)=O)=O)=O)CCC3)=O)=O)CCC1
Reference

1: Sklirou AD, Ralli M, Dominguez M, Papassideri I, Skaltsounis AL, Trougakos IP. Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Redox Biol. 2015 Aug;5:205-15. doi: 10.1016/j.redox.2015.04.010. Epub 2015 Apr 29. PubMed PMID: 25974626; PubMed Central PMCID: PMC4434199.
2: Gruber JV, Ludwig P, Holtz R. Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro. J Cosmet Sci. 2013 Mar-Apr;64(2):79-87. PubMed PMID: 23578831.

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