CONTACT US
Home > Inhibitors/Agonists> > Hexobarbital sodium
50-09-9-Hexobarbital sodium Hexobarbital sodium

Hexobarbital sodium

For research use only. Not for therapeutic Use.

  • CAT Number: I028742
  • CAS Number: 50-09-9
  • Molecular Formula: C12H15N2NaO3
  • Molecular Weight: 258.25
  • Purity: 98%
Inquiry Now
Related Small Molecules: PACAP (1-38), amide, Biotin-labeled     LIN28 inhibitor LI71     Memogain    

Hexobarbital sodium is a barbiturate that is effective as a hypnotic and sedative.


Catalog Number I028742
CAS Number 50-09-9
Synonyms

Hexobarbital sodium; NSC255103; NSC-255103; NSC 255103

Molecular Formula C12H15N2NaO3
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-1,5-dimethyl-, sodium salt
InChI InChI=1S/C12H16N2O3.Na/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16;/h6H,3-5,7H2,1-2H3,(H,13,15,17);/q;+1/p-1
InChIKey SQMCFUSVGSBKFK-UHFFFAOYSA-M
SMILES O=C1[N-]C(C(C)(C2=CCCCC2)C(N1C)=O)=O.[Na+]
Reference

1: van der Graaff M, Vermeulen NP, Breimer DD. Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metab Rev. 1988;19(2):109-64. doi: 10.3109/03602538809049621. PMID: 3069420.
2: Holcomb RR, Gerber N, Bush MT. The metabolic fate of hexobarbital in the rat. J Pharmacol Exp Ther. 1974 Jan;188(1):15-26. PMID: 4809266.
3: Gut I, Becker BA. Heredity of hexobarbital sleeping time and efficiency of drug metabolism in Wistar and Sprague-Dawley rats. Arch Toxicol. 1975 Sep 5;34(1):61-70. doi: 10.1007/BF00353340. PMID: 1242637.
4: Stumpf C, Chiari I. Echte Gewöhnung an Hexobarbital [True hexobarbital tolerance]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Jul 26;251(3):275-87. German. PMID: 4222703.
5: Boonstra-Nieveld IH, van Bezooijen CF. Pharmacokinetics of hexobarbital in young and old rats. Mech Ageing Dev. 1989 Dec;50(3):289-98. doi: 10.1016/0047-6374(89)90106-1. PMID: 2630837.
6: Korkmaz S, Ljungblad E, Wahlström G. Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat. Brain Res. 1995 Apr 10;676(2):371-7. doi: 10.1016/0006-8993(95)00132-a. PMID: 7614008.
7: Benowitz NL, Nguyen TL, Jones RT, Herning RI, Bachman J. Metabolic and psychophysiologic studies of cannabidiol-hexobarbital interaction. Clin Pharmacol Ther. 1980 Jul;28(1):115-20. doi: 10.1038/clpt.1980.139. PMID: 7389248.
8: Knodell RG, Dubey RK, Wilkinson GR, Guengerich FP. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation. J Pharmacol Exp Ther. 1988 Jun;245(3):845-9. PMID: 3385644.
9: Vermeulen NP, Danhof M, Setiawan I, Breimer DD. Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia. J Pharmacol Exp Ther. 1983 Jul;226(1):201-5. PMID: 6864540.
10: Richter E, Breimer DD, Zilly W. Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents. Eur J Clin Pharmacol. 1980;17(3):197-202. doi: 10.1007/BF00561900. PMID: 7363932.

Request a Quote