Hexokinase 2 inhibitor 1

• CAT Number: I040185
• CAS Number: 2454676-05-0
• Molecular Formula: C14H11N3O6
• Molecular Weight: 317.25
• Purity: ≥95%
• Synonyms: 4-nitro-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]benzamide
• InChI: InChI=1S/C14H11N3O6/c18-11-6-3-9(12(19)13(11)20)7-15-16-14(21)8-1-4-10(5-2-8)17(22)23/h1-7,18-20H,(H,16,21)/b15-7+
• InChIKey: OQNGYRBQYWPKIC-VIZOYTHASA-N
• SMILES: C1=CC(=CC=C1C(=O)NN=CC2=C(C(=C(C=C2)O)O)O)[N+](=O)[O-]

Hexokinase 2 inhibitor 1 (Cat No.: I040185) is a small-molecule compound that targets hexokinase 2 (HK2), an enzyme critical for the first step of glucose metabolism. Overexpression of HK2 is commonly observed in cancer cells, contributing to their rapid growth by increasing glycolysis (the Warburg effect). By inhibiting HK2, this compound can disrupt the metabolic pathways that sustain tumor growth, making it a promising candidate in cancer therapy. It is being studied for its potential to target metabolic vulnerabilities in various cancers, including solid tumors and leukemia.

Reference

[1]. Juszczak K, et al. Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups. Int J Mol Sci. 2022 Feb 27;23(5):2616.
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