For research use only. Not for therapeutic Use.
HFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 2.01 μM[1].
| Catalog Number | I011259 |
| CAS Number | 332164-34-8 |
| Synonyms | ethyl 2-amino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate |
| Molecular Formula | C17H16N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H16N2O4/c1-2-22-17(21)15-14(10-4-3-7-19-9-10)12-6-5-11(20)8-13(12)23-16(15)18/h3-9,14,20H,2,18H2,1H3 |
| InChIKey | JOPNHSIHFSZJMB-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(OC2=C(C1C3=CN=CC=C3)C=CC(=C2)O)N |
| Reference | [1]. Albiston AL, et al. Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobicpacking point at the active site of insulin-regulated aminopeptidase. Mol Pharmacol. 2010 Oct;78(4):600-7. |
