HGG-52

• CAT Number: I028753
• CAS Number: 77704-19-9
• Molecular Formula: C19H25Cl2N3O3
• Molecular Weight: 414.33
• Purity: 98%
• Synonyms: HGG52; HGG 52; HGG-52
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-[1-[[2-[(2E)-2-hydroxyiminoethyl]pyridin-1-ium-1-yl]methoxymethyl]pyridin-1-ium-3-yl]-3-methylbutan-1-one;dichloride
• InChI: InChI=1S/C19H24N3O3.2ClH/c1-16(2)12-19(23)17-6-5-10-21(13-17)14-25-15-22-11-4-3-7-18(22)8-9-20-24;;/h3-7,9-11,13,16H,8,12,14-15H2,1-2H3;2*1H/q+1;;/p-1/b20-9+
• InChIKey: TVEIEEDDUQSMAI-ZVLLBXMWSA-M
• SMILES: CC(C)CC(=O)C1=C[N+](=CC=C1)COC[N+]2=CC=CC=C2C/C=N/O.[Cl-].[Cl-]

HGG-52(CAT: I028753) is a small-molecule inhibitor targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density lipoprotein (LDL) receptor degradation. By disrupting the interaction between PCSK9 and the LDL receptor, HGG-52 enhances receptor recycling and promotes increased clearance of LDL cholesterol from the bloodstream. This compound has shown potential in preclinical studies for the treatment of hypercholesterolemia and cardiovascular diseases. HGG-52 is a valuable tool for exploring PCSK9-related mechanisms and developing novel therapeutic strategies to combat cholesterol-associated disorders, offering promise in lipid metabolism and cardiovascular health research.