For research use only. Not for therapeutic Use.
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2[1].
HHS-0701 (0.1, 0.25, 0.5, 1, 2.5, 5, 10, 25 μM; 2 hours) results concentration-dependent blockade of probe labeling in treatment of recombinant PTGR2 overexpressing HEK293T cells[1].
| Catalog Number | I042013 |
| CAS Number | 2851993-91-2 |
| Synonyms | (4-phenylpiperidin-1-yl)-[4-(1,2,4-triazol-1-ylsulfonyl)phenyl]methanone |
| Molecular Formula | C20H20N4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20N4O3S/c25-20(23-12-10-17(11-13-23)16-4-2-1-3-5-16)18-6-8-19(9-7-18)28(26,27)24-15-21-14-22-24/h1-9,14-15,17H,10-13H2 |
| InChIKey | LLBIFOHOSLRVRY-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1C2=CC=CC=C2)C(=O)C3=CC=C(C=C3)S(=O)(=O)N4C=NC=N4 |
| Reference | [1]. Emmanuel K Toroitich, et al.Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. |
