For research use only. Not for therapeutic Use.
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].
Catalog Number | I041758 |
CAS Number | 2734922-78-0 |
Synonyms | (2S)-1′-chloro-8-(difluoromethoxy)-8′,8′-difluoro-6-(trifluoromethyl)spiro[3H-imidazo[1,2-a]pyridine-2,5′-6,7-dihydroisoquinoline] |
Molecular Formula | C17H11ClF7N3O |
Purity | ≥95% |
InChI | InChI=1S/C17H11ClF7N3O/c18-12-11-9(1-4-26-12)15(2-3-16(11,21)22)7-28-6-8(17(23,24)25)5-10(13(28)27-15)29-14(19)20/h1,4-6,14H,2-3,7H2/t15-/m1/s1 |
InChIKey | OARXSQSRBRVMQA-OAHLLOKOSA-N |
SMILES | C1CC(C2=C(C13CN4C=C(C=C(C4=N3)OC(F)F)C(F)(F)F)C=CN=C2Cl)(F)F |
Reference | [1]. Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1. |