HIF-2α-IN-8

For research use only. Not for therapeutic Use.

  • CAT Number: I041758
  • CAS Number: 2734922-78-0
  • Molecular Formula: C17H11ClF7N3O
  • Molecular Weight: 441.73
  • Purity: ≥95%
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HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].


Catalog Number I041758
CAS Number 2734922-78-0
Synonyms

(2S)-1′-chloro-8-(difluoromethoxy)-8′,8′-difluoro-6-(trifluoromethyl)spiro[3H-imidazo[1,2-a]pyridine-2,5′-6,7-dihydroisoquinoline]

Molecular Formula C17H11ClF7N3O
Purity ≥95%
InChI InChI=1S/C17H11ClF7N3O/c18-12-11-9(1-4-26-12)15(2-3-16(11,21)22)7-28-6-8(17(23,24)25)5-10(13(28)27-15)29-14(19)20/h1,4-6,14H,2-3,7H2/t15-/m1/s1
InChIKey OARXSQSRBRVMQA-OAHLLOKOSA-N
SMILES C1CC(C2=C(C13CN4C=C(C=C(C4=N3)OC(F)F)C(F)(F)F)C=CN=C2Cl)(F)F
Reference

[1]. Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.

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