HIF-2a Translation Inhibitor 76

• CAT Number: I047617
• CAS Number: 882268-69-1
• Molecular Formula: C9H9N3O4S2
• Molecular Weight: 287.32
• Purity: ≥95%
• IUPAC Name: methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate
• InChI: InChI=1S/C9H9N3O4S2/c1-16-9(13)8-6(3-4-17-8)11-12-7(5-10)18(2,14)15/h3-4,11H,1-2H3/b12-7+
• SMILES: COC(=O)C1=C(C=CS1)N/N=C(\C#N)/S(=O)(=O)C

HIF-2a translation inhibitor (IC50 value 5 µM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
KEYWORDS: HIF-2a Translation Inhibitor 76 | supplier | HIF2a translation inhibitor | CAS [882268-69-1] | DNA-RNA | HIF-2α | Transcription Factor | Iron-Responsive Element | IRE | mTOR | hypoxia | IRP1

Reference

M Zimmer et al. Small-molecule inhibitors of HIF-2a translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008 Dec 26;32(6):838-48.