HIF-IN-1

• CAT Number: I043686
• CAS Number: 2393928-76-0
• Molecular Formula: C17H12N2O
• Molecular Weight: 260.29
• Purity: ≥95%
• Synonyms: 3-(4-methylphenyl)indeno[2,1-c]pyrazol-4-one
• InChI: InChI=1S/C17H12N2O/c1-11-6-8-12(9-7-11)19-16-15(10-18-19)13-4-2-3-5-14(13)17(16)20/h2-10H,1H3
• InChIKey: ZMPVOQJDQIWRJZ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)N2C3=C(C=N2)C4=CC=CC=C4C3=O

HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1].

Reference

[1]. Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28(1):115207.
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