HIF1-IN-3

• CAT Number: I043537
• CAS Number: 333314-79-7
• Molecular Formula: C26H24N2O3
• Molecular Weight: 412.48
• Purity: ≥95%
• Synonyms: N-[(8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]-3-phenylpropanamide
• InChI: InChI=1S/C26H24N2O3/c1-31-21-13-10-20(11-14-21)24(28-23(29)16-9-18-6-3-2-4-7-18)22-15-12-19-8-5-17-27-25(19)26(22)30/h2-8,10-15,17,24,30H,9,16H2,1H3,(H,28,29)
• InChIKey: RFCCQJJHFAITGH-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C(C2=C(C3=C(C=CC=N3)C=C2)O)NC(=O)CCC4=CC=CC=C4

HIF1-IN-3 (compound F4) is a potent HIF1 inhibitor with an EC50 value of 0.9 μM. HIF1-IN-3 can be used for researching anticancer[1].

Reference

[1]. Poloznikov AA, et al. Structure-activity relationship for branched oxyquinoline HIF activators: Effect of modifications to phenylacetamide “tail”. Biochimie. 2017;133:74-79.
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