For research use only. Not for therapeutic Use.
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1].
Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].
Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].
| Catalog Number | M126992 |
| CAS Number | 173933-40-9 |
| Synonyms | (3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one |
| Molecular Formula | C12H12O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6- |
| InChIKey | QDVIEIMMEUCFMW-QXYPORFMSA-N |
| SMILES | CC(=O)C=C(C=CC1=CC(=C(C=C1)O)O)O |
| Reference | [1]. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017. [2]. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. [3]. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. [4]. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. |
