Histone Acetyltransferase Inhibitor II

• CAT Number: I005537
• CAS Number: 932749-62-7
• Molecular Formula: C20H16Br2O3
• Molecular Weight: 464.20
• Purity: ≥95%
• Synonyms: 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-cyclohexanone
• Target: Histone Acetyltransferases
• Solubility: DMSO ≥ 30 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one
• InChI: InChI=1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
• InChIKey: YOLKEKNTCBWPSD-VOMDNODZSA-N
• SMILES: C1C/C(=C\C2=CC(=C(C=C2)O)Br)/C(=O)/C(=C/C3=CC(=C(C=C3)O)Br)/C1

Histone Acetyltransferase Inhibitor II (Cat No.:I005537) represents a significant advancement in the field of epigenetics and cell therapy. This inhibitor effectively modulates histone acetyltransferase activity, influencing the acetylation of histones and subsequently regulating gene expression. In the context of insulin-producing cells, the inhibitor plays a pivotal role in enhancing their capability to secrete blood glucose-regulating hormones, including insulin, in response to physiological signals. This innovative method of production holds promise for generating functional insulin-secreting cells for diabetes treatment.

Reference

[1]. PCT Int. Appl. (2016), WO 2016038038 A1 20160317.