For research use only. Not for therapeutic Use.
HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). HJC 0350 displays no effect on Epac1. HJC 0350 blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
| Catalog Number | R062078 |
| CAS Number | 885434-70-8 |
| Synonyms | 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole |
| Molecular Formula | C15H19NO2S |
| Purity | ≥95% |
| Target | GTPase |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4C |
| InChI | InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3 |
| InChIKey | AFZWZVLPIMHLSE-UHFFFAOYSA-N |
| SMILES | CC1=C(S(N2C=C(C)C=C2C)(=O)=O)C(C)=CC(C)=C1 |
| Reference | </br>1. Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952. PMID: 23286832.</br> |
