HJC0152 (hydrochloride)

• CAT Number: R067116
• CAS Number: 1420290-99-8
• Molecular Formula: C15H13Cl2N3O4 • HCl
• Molecular Weight: 406.65
• Purity: ≥95%
• Synonyms: 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)-benzamide, monohydrochloride
• Target: Stem Cell/Wnt
• Storage: -20°C
• IUPAC Name: 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide;hydrochloride
• InChI: InChI=1S/C15H13Cl2N3O4.ClH/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17;/h1-4,7-8H,5-6,18H2,(H,19,21);1H
• InChIKey: XRZHLOYBZOONSZ-UHFFFAOYSA-N
• SMILES: ClC1=C(NC(C2=C(OCCN)C=CC(Cl)=C2)=O)C=CC([N+]([O-])=O)=C1.Cl

HJC0152 (hydrochloride) is a selective inhibitor of the protein-protein interaction between MDM2 and p53, essential for regulating the tumor suppressor protein p53. By disrupting this interaction, HJC0152 (hydrochloride) reactivates p53, promoting apoptosis in cancer cells. This compound holds significant potential for cancer therapy, particularly in tumors with p53 dysfunction. Its ability to restore p53 function makes it a promising candidate for targeted cancer treatments, especially in overcoming p53 mutations that are prevalent in various cancers.