For research use only. Not for therapeutic Use.
HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical[1].
HKSOX-1 (10 μM) reacts with O2?- in potassium phosphate buffer at 25 °C to produce a dramatic time-dependent fluorescence increase, which is completed within 10 min, and the fluorescence intensity remains unchanged within 60 min[1].?
HKSOX-1 (10 μM) exhibits excellent stability toward pH changes in the range of 2.2-8.8[1].
| Catalog Number | I045485 |
| Synonyms | 2′,4′,5′,7′-tetrafluoro-3-oxo-3′,6′-bis(trifluoromethylsulfonyloxy)spiro[2-benzofuran-1,9′-xanthene]-5-carboxylic acid |
| Molecular Formula | C23H6F10O11S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H6F10O11S2/c24-11-4-9-15(13(26)17(11)43-45(37,38)22(28,29)30)41-16-10(5-12(25)18(14(16)27)44-46(39,40)23(31,32)33)21(9)8-2-1-6(19(34)35)3-7(8)20(36)42-21/h1-5H,(H,34,35) |
| InChIKey | XSHHIFZGVZWRBI-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1C(=O)O)C(=O)OC23C4=CC(=C(C(=C4OC5=C(C(=C(C=C35)F)OS(=O)(=O)C(F)(F)F)F)F)OS(=O)(=O)C(F)(F)F)F |
| Reference | [1]. Hu JJ, et, al. Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. J Am Chem Soc. 2015 Jun 3;137(21):6837-43. |
