HL 010183

• CAT Number: I047590
• CAS Number: 1429218-03-0
• Molecular Formula: C14H20N6.HCl
• Molecular Weight: 308.81
• Purity: ≥95%
• IUPAC Name: 2-N,2-N-dimethyl-4-N-(2-propylphenyl)-1,3,5-triazine-2,4,6-triamine;hydrochloride
• InChI: InChI=1S/C14H20N6.ClH/c1-4-7-10-8-5-6-9-11(10)16-13-17-12(15)18-14(19-13)20(2)3;/h5-6,8-9H,4,7H2,1-3H3,(H3,15,16,17,18,19);1H
• SMILES: CCCC1=CC=CC=C1NC2=NC(=NC(=N2)N)N(C)C.Cl

A metformin derivative exerting a potent anti-tumor effect; HL010183 inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells; 100 fold more potent than metformin.
KEYWORDS: HL 010183 | supplier | Antitumor agent | HL010183 | HL-010183 | CAS [1429218-03-0] | [1125365-14-1] | Glucose | Homeostasis | AMPK | metformin | anti-tumor | proliferation | Hs578T | breast cancer

Reference

M Koh et al. A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells. Bioorg. Med. Chem. 2013, 21(8), 2305-2313.