For research use only. Not for therapeutic Use.
Hdm-2 (human double minute-2; Mdm-2 in mouse) is a ubiquitin ligase and key negative regulator of p53, targeting it for proteasomal degradation. Overexpression of Hdm-2 in some tumors leads to inactivation of p53, thereby allowing tumor cells to escape p53-induced apoptosis. HLI 373 is an inhibitor of Hdm-2. At concentrations of 5-50 µM, it selectively inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53. Through these actions, HLI 373 stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and mouse embryo fibroblasts harboring wild-type p53.
| Catalog Number | R065737 |
| CAS Number | 1782531-99-0 |
| Synonyms | 5-[[3-(dimethylamino)propyl]amino]-3,10-dimethyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, dihydrochloride |
| Molecular Formula | C18H23N5O2 • 2HCl |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | -20°C |
| InChI | InChI=1S/C18H23N5O2.2ClH/c1-21(2)11-7-10-19-15-12-8-5-6-9-13(12)22(3)16-14(15)17(24)23(4)18(25)20-16;;/h5-6,8-9,19H,7,10-11H2,1-4H3;2*1H |
| InChIKey | WUEMKAQTAIRDOA-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(NCCCN(C)C)C2=CC=CC=C2N(C)C1=N3)N(C)C3=O.Cl.Cl |
| Reference | 1.Chène, P. Inhibiting the p53-MDM2 interaction: An important target for cancer therapy. Nature Reviews.Cancer 3, 102-109 (2003). |
