HM-30181 hydrochloride

• CAT Number: I028801
• CAS Number: 849675-88-3
• Molecular Formula: C38H37ClN6O7
• Molecular Weight: 725.21
• Purity: 98%
• Synonyms: Encequidar HCl; Encequidar hydrochloride; HM-30181 hydrochloride; HM30181 hydrochloride; HM 30181 hydrochloride; HM-30181 HCl; HM30181 HCl; HM 30181 HCl
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxochromene-2-carboxamide;hydrochloride
• InChI: InChI=1S/C38H36N6O7.ClH/c1-47-32-17-24-14-16-43(22-25(24)18-33(32)48-2)15-13-23-9-11-26(12-10-23)44-41-37(40-42-44)28-19-34(49-3)35(50-4)20-29(28)39-38(46)36-21-30(45)27-7-5-6-8-31(27)51-36;/h5-12,17-21H,13-16,22H2,1-4H3,(H,39,46);1H
• InChIKey: KAQQJKZDBBMBEZ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)N4N=C(N=N4)C5=CC(=C(C=C5NC(=O)C6=CC(=O)C7=CC=CC=C7O6)OC)OC)OC.Cl

HM-30181 Hydrochloride(CAT: I028801) is a potent and selective inhibitor of P-glycoprotein (P-gp), a key efflux transporter involved in multidrug resistance (MDR). By blocking P-gp activity, it enhances the intracellular concentration and efficacy of chemotherapeutic agents. This compound is particularly valuable in oncology research, aiding studies focused on overcoming drug resistance in cancer cells. HM-30181 Hydrochloride serves as a critical tool for investigating P-gp-mediated drug transport, optimizing drug delivery, and developing strategies to counteract MDR in cancer therapy.