HM43239

• CAT Number: I047301
• CAS Number: 2569527-64-4
• Molecular Formula: C29H33ClN6
• Molecular Weight: 501.07
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1CN(CC(C)N1)CC2=CC(=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC(=C5)C)C6CC6

HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s’ of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.

Reference

[1] Miyoung Lee, et al. Cancer Research AM2018-804 Published July 2018.