hMAO-B/MB-COMT-IN-1

• CAT Number: I042823
• CAS Number: 254974-70-4
• Molecular Formula: C16H19NO3
• Molecular Weight: 273.33
• Purity: ≥95%
• Synonyms: (2E,4E)-5-(3,4-dihydroxyphenyl)-1-piperidin-1-ylpenta-2,4-dien-1-one
• InChI: InChI=1S/C16H19NO3/c18-14-9-8-13(12-15(14)19)6-2-3-7-16(20)17-10-4-1-5-11-17/h2-3,6-9,12,18-19H,1,4-5,10-11H2/b6-2+,7-3+
• InChIKey: ZSGNXVFMAMFAQY-YPCIICBESA-N
• SMILES: C1CCN(CC1)C(=O)C=CC=CC2=CC(=C(C=C2)O)O

hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD)[1].
hMAO-B/MB-COMT-IN-1 (compound 3, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-1 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-1 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells[1].
hMAO-B/MB-COMT-IN-1 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit[1].

Reference

[1]. Daniel Chavarria, et al. Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor. Eur J Med Chem. 2022 Sep 8;243:114740.
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