HMPSNE

• CAT Number: I028811
• CAS Number: 459420-09-8
• Molecular Formula: C17H14N2O2S
• Molecular Weight: 310.37
• Purity: 98%
• Synonyms: HMPSNE; HMP SNE; HMP-SNE; I3MT-3; I3MT3; I3MT 3
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)-1-(naphthalen-1-yl)ethan-1-one
• InChI: InChI=1S/C17H14N2O2S/c1-11-9-16(21)19-17(18-11)22-10-15(20)14-8-4-6-12-5-2-3-7-13(12)14/h2-9H,10H2,1H3,(H,18,19,21)
• InChIKey: KKPLVAUVHOSUPR-UHFFFAOYSA-N
• SMILES: O=C(C1=C2C=CC=CC2=CC=C1)CSC3=NC(C)=CC(O)=N3

I3MT-3 (Cat No.: I028811), also known as HMPSNE, is an effective, selective and membrane-permeable inhibitor of 3-mercaptopyruvate sulfurtransferase (IC50=2.7μM) for other hydrogen sulfide/ Sulfasulfase is not active. I3MT-3 targets superthiocysteine residues located in the active site of 3MST.

Reference

1: Bantzi M, Augsburger F, Loup J, Berset Y, Vasilakaki S, Myrianthopoulos V, Mikros E, Szabo C, Bochet CG. Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer. J Med Chem. 2021 Apr 15. doi: 10.1021/acs.jmedchem.1c00260. Epub ahead of print. PMID: 33856792.
2: Ascenção K, Dilek N, Augsburger F, Panagaki T, Zuhra K, Szabo C. Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells. Pharmacol Res. 2021 Mar;165:105393. doi: 10.1016/j.phrs.2020.105393. Epub 2021 Jan 20. PMID: 33484818.
3: Augsburger F, Randi EB, Jendly M, Ascencao K, Dilek N, Szabo C. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Biomolecules. 2020 Mar 13;10(3):447. doi: 10.3390/biom10030447. PMID: 32183148; PMCID: PMC7175125.