For research use only. Not for therapeutic Use.
HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC50 of 37 nM for KCNQ2[1].
HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1].
| Catalog Number | I043861 |
| CAS Number | 1821222-10-9 |
| Synonyms | methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynylamino]-2,6-dimethylphenyl]carbamate |
| Molecular Formula | C20H21FN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21FN2O2/c1-5-10-23(13-16-6-8-17(21)9-7-16)18-11-14(2)19(15(3)12-18)22-20(24)25-4/h1,6-9,11-12H,10,13H2,2-4H3,(H,22,24) |
| InChIKey | HXUBJZRAVCPBRH-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=C1NC(=O)OC)C)N(CC#C)CC2=CC=C(C=C2)F |
| Reference | [1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837. |
