HO-PEG11-OH

• CAT Number: I016371
• CAS Number: 6809-70-7
• Molecular Formula: C₂₂H₄₆O₁₂
• Molecular Weight: 502.59
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
• InChIKey: ADLFUPFRVXCDMO-LIGXYSTNSA-M
• SMILES: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)[O-].[Na+]

HO-PEG11-OH（Cat No.:I016371） is a polyethylene glycol (PEG)-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are bifunctional molecules that consist of a ligand for a specific target protein, a linker, and a ligand for an E3 ubiquitin ligase. The linker connects the two ligands, allowing for the recruitment of the target protein to the E3 ligase, leading to its ubiquitination and subsequent degradation. HO-PEG11-OH acts as a flexible and hydrophilic linker, providing the necessary space and solubility for proper PROTAC function in targeted protein degradation strategies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562