HODHBt

For research use only. Not for therapeutic Use.

  • CAT Number: I028828
  • CAS Number: 28230-32-2
  • Molecular Formula: C7H5N3O2
  • Molecular Weight: 163.13
  • Purity: ≥95%
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HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].
HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1].
HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1].
HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1].
HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1].


Catalog Number I028828
CAS Number 28230-32-2
Synonyms

3-hydroxy-1,2,3-benzotriazin-4-one

Molecular Formula C7H5N3O2
Purity ≥95%
InChI InChI=1S/C7H5N3O2/c11-7-5-3-1-2-4-6(5)8-9-10(7)12/h1-4,12H
InChIKey HJBLUNHMOKFZQX-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)C(=O)N(N=N2)O
Reference

[1]. Macedo AB, et al. The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation. J Virol. 2022 Aug 10;96(15):e0037222.
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