HOE 33187

• CAT Number: I002793
• CAS Number: 23623-08-7
• Molecular Formula: C25H24N6
• Molecular Weight: 408.50
• Purity: ≥95%
• Synonyms: 6-(4-methylpiperazin-1-yl)-2/’-phenyl-1H,3/’H-2,5/’-bibenzo[d]imidazole
• Target: DNA Stain
• Solubility: DMSO or water Protect from light
• Storage: Store at -20°C
• IUPAC Name: 6-(4-methylpiperazin-1-yl)-2-(2-phenyl-3H-benzimidazol-5-yl)-1H-benzimidazole
• InChI: InChI=1S/C25H24N6/c1-30-11-13-31(14-12-30)19-8-10-21-23(16-19)29-25(27-21)18-7-9-20-22(15-18)28-24(26-20)17-5-3-2-4-6-17/h2-10,15-16H,11-14H2,1H3,(H,26,28)(H,27,29)
• InChIKey: SOUKAPYFWOYMNH-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=CC=C6

HOE 33187（Cat No.:I002793）is a selective and potent inhibitor of the enzyme 5-lipoxygenase (5-LOX), which is involved in the biosynthesis of leukotrienes, inflammatory mediators linked to conditions like asthma, allergic rhinitis, and inflammatory bowel diseases. By inhibiting 5-LOX, HOE 33187 aims to reduce leukotriene production and alleviate inflammation, making it a potential therapeutic candidate for inflammatory disorders. Preclinical studies have shown promising anti-inflammatory effects, and it is being explored as a possible treatment option for conditions where leukotrienes play a significant pathogenic role. Further research and clinical trials are needed to assess its efficacy and safety.

Reference

[1]. Latt SA, Stetten G, Juergens LA, Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 23 (7): 493-505.

[2]. a b c /Hoechst Stains/. Invitrogren (Molecular Probes).

[3]. Portugal J, Waring MJ. Assignment of DNA binding sites for 4/’,6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study. Biochimica et Biophysica Acta 949 (2): 158-68.