HOE-S 785026

• CAT Number: I001251
• CAS Number: 132869-83-1
• Molecular Formula: C25H24N6O
• Molecular Weight: 424.5
• Purity: ≥95%
• Synonyms: 3-(6-(4-methylpiperazin-1-yl)-1H,3/’H-[2,5/’-bibenzo[d]imidazol]-2/’-yl)phenol
• Target: DNA Stain
• Solubility: DMSO: ≥ 37 mg/mL, Protect from light
• Storage: Store at -20°C
• IUPAC Name: 3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol
• InChI: 1S/C25H24N6O/c1-30-9-11-31(12-10-30)18-6-8-21-23(15-18)29-25(27-21)17-5-7-20-22(14-17)28-24(26-20)16-3-2-4-19(32)13-16/h2-8,13-15,32H,9-12H2,1H3,(H,26,28)(H,27,29)
• InChIKey: WOFDIDGQAOQHGY-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=CC=C6)O

HOE-S 785026 (Cat No.: I001251) is a selective non-peptide antagonist of the vasopressin V1a receptor, involved in regulating vascular tone, blood pressure, and social behavior. By blocking V1a receptors, it inhibits vasopressin-induced vasoconstriction, making it useful in studying cardiovascular and renal physiology. HOE-S 785026 has been employed in preclinical research to explore therapeutic approaches for hypertension, heart failure, and central nervous system disorders. Its selectivity and potency provide valuable insights into vasopressin signaling and the development of V1a-targeted therapeutic strategies.

Reference

[1]. Latt SA, Stetten G, Juergens LA, Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 23 (7): 493-505.
[2]. a b c /Hoechst Stains/. Invitrogren (Molecular Probes).
[3]. Portugal J, Waring MJ. Assignment of DNA binding sites for 4/’,6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study. Biochimica et Biophysica Acta 949 (2): 158-68.