HOIPIN-8

• CAT Number: I047640
• CAS Number: 2519537-69-8
• Molecular Formula: C23H15F2N4NaO3
• Molecular Weight: 456.38
• Purity: ≥95%
• IUPAC Name: 2-[(E)-3-[2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl]-3-oxoprop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoic acid
• InChI: InChI=1S/C23H16F2N4O3/c1-29-12-17(11-28-29)13-2-4-18(23(31)32)14(6-13)3-5-21(30)22-19(24)7-15(8-20(22)25)16-9-26-27-10-16/h2-12H,1H3,(H,26,27)(H,31,32)/b5-3+
• SMILES: CN1C=C(C=N1)C2=CC(=C(C=C2)C(=O)O)/C=C/C(=O)C3=C(C=C(C=C3F)C4=CNN=C4)F

HOIPIN-8 is a potent inhibitor of LUBAC and NF-κB signaling without cytotoxicity (IC50 value of 11 nM). Powerful tool to explore the physiological functions of LUBAC.
KEYWORDS: HOIPIN-8 | supplier | LUBAC inhibitor | HOIPIN8 | HOIPIN 8 | CAS [2519537-70-1] – [2519537-69-8] | NF-κB Pathway | Ubiquitin Ligase (E3; LUBAC) | Inhibitor | Enzymes

Reference

K Katsuya et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706.