For research use only. Not for therapeutic Use.
HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect[1][2].
HOKU-81 (4-Hydroxytulobuterol) is approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs[1].
| Catalog Number | I004165 |
| CAS Number | 58020-43-2 |
| Synonyms | 4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol |
| Molecular Formula | C12H18ClNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H18ClNO2/c1-12(2,3)14-7-11(16)9-5-4-8(15)6-10(9)13/h4-6,11,14-16H,7H2,1-3H3 |
| InChIKey | LIXBJWRFCNRAPA-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NCC(C1=C(C=C(C=C1)O)Cl)O |
| Reference | [1]. Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8. [2]. Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24. |
