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80-49-9-Homatropine Methylbromide Homatropine Methylbromide

Homatropine Methylbromide

For research use only. Not for therapeutic Use.

  • CAT Number: A000406
  • CAS Number: 80-49-9
  • Molecular Formula: C17H24BrNO3
  • Molecular Weight: 370.28
  • Purity: ≥95%
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Related Small Molecules: Piracetam     Cefdinir     Uridine    

Homatropine Methylbromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics. It is used, in addition to papaverine, as component of mild drugs that help /flush/ the bile.


Catalog Number A000406
CAS Number 80-49-9
Synonyms

Arkitropin; 80-49-9; Homatropine (methylbromide); Camatropine; Homatromide

Molecular Formula C17H24BrNO3
Purity ≥95%
Target AChR
Solubility >15mg/mL in DMSO
Storage -20°C
InChI 1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15?,16?;
InChIKey FUFVKLQESJNNAN-ZZJGABIISA-M
SMILES C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
Reference

1: Canaes LS, Leite OD, Fatibello-Filho O. Flow-injection turbidimetric
determination of homatropine methylbromide in pharmaceutical formulations using
silicotungstic acid as precipitant reagent. Talanta. 2006 Mar 15;69(1):239-42.
doi: 10.1016/j.talanta.2005.09.035. Epub 2005 Oct 28. PubMed PMID: 18970560.
<br>

2: Knochen M, Bardanca M, Piaggio P. Application of second-derivate UV
spectrophotometry to the determination of homatropine methylbromide in
single-component dosage form. Boll Chim Farm. 1987 Jul;126(7):294-7. PubMed PMID:
3452330.
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3: Hanna S, Rosen M, Rasero L, Lachman L. Analysis of homatropine methylbromide
dosage forms. J Pharm Sci. 1977 Jan;66(1):123-4. PubMed PMID: 576237.
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4: Cantwell FF, Domjan M, Hiskey CF. Specific analysis for homatropine
methylbromide in syrups. J Pharm Sci. 1974 Apr;63(4):599-603. PubMed PMID:
4828713.

<br>
5: Grabowski BF, Softly BJ, Chang BL, Haney WG Jr. GLC analysis of homatropine
methylbromide in tablets and elixirs. J Pharm Sci. 1973 May;62(5):806-9. PubMed
PMID: 4705690.
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6: Spiegel D, Ahuja S, Brofazi FR. Stability-indicating method for analysis of
homatropine methylbromide in pharmaceutical formulations. J Pharm Sci. 1972
Oct;61(10):1630-2. PubMed PMID: 5072413.
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7: Ahuja S, Spiegel D, Brofazi FR. Stabilization of homatropine
methylbromide-iodobismuthate complex in solution for quantitative analysis of
homatropine methylbromide. J Pharm Sci. 1970 Mar;59(3):417-8. PubMed PMID:
5416194.
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8: BATTERMAN RC, MOURATOFF GJ. Influence of morphine, codeine, meperidine,
ephedrine and homatropine methylbromide upon absorption of aspirin from the
gastro-intestinal tract of man. Curr Ther Res Clin Exp. 1961 May;3:193-200.
PubMed PMID: 13687794.
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9: EDUARDO, BILLINGHURST GA. [Symptomatic treatment of Meniere/’s syndrome with
homatropine methylbromide]. Sem Med. 1960 Nov 3;117:1469-71. Spanish. PubMed
PMID: 13725767.
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10: WALTON CJ, CAYER D, SOHMER MF. Prolonged treatment of peptic ulcer with
homatropine methylbromide: a study of 58 patients under continuous therapy for
periods up to one year. N C Med J. 1959 May;20(5):181-4. PubMed PMID: 13657444.

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