Homochlorcyclizine

• CAT Number: I028856
• CAS Number: 848-53-3
• Molecular Formula: C19H23ClN2
• Molecular Weight: 314.86
• Purity: 98%
• Synonyms: Homochlorcyclizine; NSC25132; NSC-25132; NSC 25132
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-(p-Chloro-alpha-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine
• InChI: InChI=1S/C19H23ClN2/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17/h2-4,6-11,19H,5,12-15H2,1H3
• InChIKey: WEUCDJCFJHYFRL-UHFFFAOYSA-N
• SMILES: CN1CCN(C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3)CCC1

Homochlorcyclizine is an antihistamine of the diphenylmethylpiperazine group which has been marketed in Japan since 1965. It is used in the treatment of allergies and other conditions. It also has some anticholinergic, antidopaminergic, and antiserotonergic properties.

Reference

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2: Chang TS, Chen CT. Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells. Arch Pharm Res. 2012 Jan;35(1):119-27. doi: 10.1007/s12272-012-0113-z. Epub 2012 Feb 2. PMID: 22297750.
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9: Nishikata M, Nomura A, Iseki K, Miyazaki K, Nakai A, Fushida H, Miyake K, Arita T. Enantioselective pharmacokinetics of homochlorcyclizine. II: Disposition and metabolism of (+)-, (-)- and racemic homochlorcyclizine after oral administration to man. Eur J Clin Pharmacol. 1992;43(5):533-8. doi: 10.1007/BF02285097. PMID: 1362384.
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