Homopropargylglycine

• CAT Number: I042515
• CAS Number: 215160-72-8
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14
• Purity: ≥95%
• Synonyms: 2-aminohex-5-ynoic acid
• InChI: InChI=1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
• InChIKey: SCGJGNWMYSYORS-UHFFFAOYSA-N
• SMILES: C#CCCC(C(=O)O)N

Homopropargylglycine is a Methionine (HY-13694) analogue. Homopropargylglycine is incorporated at a suitable rate into newly synthesized proteins in a variety of systems, including mammalian cell culture. Homopropargylglycine can be used to identify old and new protein populations[1]. Homopropargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Homopropargylglycine enables Bio-Orthogonal Non-Canonical Amino acid Tagging (BONCAT) of a small sample of the proteins being synthesized in Arabidopsis plants or cell cultures, facilitating their click-chemistry enrichment for analysis[1].

Reference

[1]. Tivendale ND, Millar AH, et al. In vivo homopropargylglycine incorporation enables sampling, isolation and characterization of nascent proteins from Arabidopsis thaliana. Plant J. 2021 Aug;107(4):1260-1276.
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