HPK1-IN-19

• CAT Number: I045179
• CAS Number: 2227609-33-6
• Molecular Formula: C27H32N7O2P
• Molecular Weight: 517.56
• Purity: ≥95%
• Synonyms: 4-N-(2-dimethylphosphorylphenyl)-2-N-(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)-5-(1-methylpyrazol-4-yl)pyrimidine-2,4-diamine
• InChI: InChI=1S/C27H32N7O2P/c1-33-11-10-18-13-24(36-3)23(12-19(18)16-33)31-27-28-15-21(20-14-29-34(2)17-20)26(32-27)30-22-8-6-7-9-25(22)37(4,5)35/h6-9,12-15,17H,10-11,16H2,1-5H3,(H2,28,30,31,32)
• InChIKey: AZENVIBXSMLBQC-UHFFFAOYSA-N
• SMILES: CN1CCC2=CC(=C(C=C2C1)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)C5=CN(N=C5)C)OC

HPK1-IN-19 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2018102366A1 compound I-47[1].

Reference

[1]. Huang WS, et, al. Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors. WO2018102366A1.