HPK1-IN-2

• CAT Number: I047303
• CAS Number: 2056122-11-1
• Molecular Formula: C19H20N6OS
• Molecular Weight: 380.47
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(NC4=O)SC=C5

HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase), Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity.

Reference

[1] Peter Brent Sampson, et al. WO2016205942A1.