For research use only. Not for therapeutic Use.
HPK1-IN-32 is a potent and selective HPK1 inhibitor with an IC50 of 65 nM. HPK1-IN-32 can be used for the research of HPK1 related disorders or diseases[1].
HPK1-IN-32 (Example A34, 0-2 μM, 2 h) inhibits cellular pSLP76 activity with an IC50 of 65 nM in Jurkat cell line[1].
| Catalog Number | I041760 |
| CAS Number | 2766481-17-6 |
| Synonyms | 4-[5-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]oxypyrazin-2-yl]-N-[2-[(3R)-3-fluoropyrrolidin-1-yl]ethyl]-2,6-dimethylbenzamide |
| Molecular Formula | C28H37FN8O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H37FN8O2/c1-18-12-20(13-19(2)25(18)27(38)31-7-11-36-10-4-21(29)16-36)24-15-32-26(30)28(34-24)39-23-14-33-37(17-23)22-5-8-35(3)9-6-22/h12-15,17,21-22H,4-11,16H2,1-3H3,(H2,30,32)(H,31,38)/t21-/m1/s1 |
| InChIKey | IGTYEXMPMYGLTR-OAQYLSRUSA-N |
| SMILES | CC1=CC(=CC(=C1C(=O)NCCN2CCC(C2)F)C)C3=CN=C(C(=N3)OC4=CN(N=C4)C5CCN(CC5)C)N |
| Reference | [1]. Sanjia XU, et al. 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof. Patent. WO2022068848. |
